Genetic Regulation of Endothelial Vasomotor Function
نویسندگان
چکیده
منابع مشابه
Genetic Regulation of Endothelial Vasomotor Function
The endothelium plays an important role in the regulation of vasomotor tone and the maintenance of vascular integrity. Endothelial dysfunction, i.e., impaired endothelial dependent dilation, is a fundamental component of the pathogenesis of cardiovascular disease. Although endothelial dysfunction is associated with a number of cardiovascular disease risk factors, those risk factors are not the ...
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The purpose of this review is to provide the anaesthetists with a comprehensive update on the endothelial-cell control of local blood flow. This single cell layer was originally thought to represent only a passive barrier. It is now evident that it plays an active role in a broad variety of biological functions. Since the discovery of the endothelial-derived relaxing factor (EDRF), it has been ...
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The initial description in 1980 by Furchgott and Zawadzki1 of endothelium-derived vasodilator factor has stimulated more than 2 decades of intense research to delineate the basic biology of the endothelium and its importance in the clinical setting.2 Endotheliumderived vasodilator factor has been identified as nitric oxide (NO).2 It is formed in endothelial cells from the amino acid L-arginine ...
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Overproduction of reactive oxygen species is closely associated with cardiovascular diseases in part by impairing endothelial function and consequently compromising blood flow regulation. Superoxide and hydrogen peroxide are elevated under various disease states with reduced endothelium-derived nitric oxide bioavailability. The oxidative stress elicited by angiotensin II, C-reactive protein and...
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BACKGROUND Sirolimus inhibits endothelial cell proliferation in vitro, but although the sirolimus-eluting stent (SES) is widely used because of the very low rates of in-stent restenosis, the influence of SES on coronary endothelial vasomotor function in humans is not well known. METHODS AND RESULTS The present study included 21 patients treated with SES, and 12 patients treated with conventio...
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ژورنال
عنوان ژورنال: Frontiers in Physiology
سال: 2016
ISSN: 1664-042X
DOI: 10.3389/fphys.2016.00571